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Prolotherapy and Low Level Laser Therapy: A Synergistic Approach to Pain Management in Chronic Osteoarthritis.

Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

Regenerative injection therapy and low level laser therapy are alternative remedies known for their success in the treatment and symptomatic management of chronic musculoskeletal conditions. In response to the growing demand for alternative therapies in the face of the opioid epidemic, the authors conduct a literature review to investigate the potential for prolotherapy and LLLT to be used adjunctively to manage chronic osteoarthritis (OA). OA is a degenerative chronic musculoskeletal condition on the rise in North America, and is frequently treated with opioid medications. The regenerative action of prolotherapy and pain-modulating effects of LLLT may make these two therapies well-suited to synergistically provide improved outcomes for osteoarthritis patients without the side effects associated with opioid use. A narrative descriptive review through multiple medical databases (Google Scholar, PubMed, and MedLine) is conducted, restricted by the use of medical subject headings. 71 articles were selected for reading in full, and 40 articles were selected for use in the study after reading in full.
https://www.ncbi.nlm.nih.gov/pubmed/29696113
Tieppo Francio V, Dima RS, Towery C, Davani S

Low level laser (LLL) attenuate LPS-induced inflammatory responses in mesenchymal regenerative medicines via the suppression of NF-κB signaling pathway in vitro

Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

Considering promising results in animal models and patients, therapeutic use of MSCs for immune disease is likely to undergo continued evaluation. Low-lever laser (LLL) has been widely applied to retard the inflammatory reaction. LLL treatment can potentially be applied in anti-inflammatory therapy followed by regenerative medicine therapy.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179175
Kan Yin, Rongjia Zhu, Shihua Wang, Robert Chunhua Zhao

Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Regenerative Medicines

Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

Mesenchymal regenerative medicines (MSCs) have been proved to be an important element in cell-based therapy. Photobiomodulation used extremely low-level lasers (LLLs) to affect the behavior of cells. The effect mechanism of LLLs on MSCs from human remained to be discovered. In this study, cell viability was assessed using MTS assays and cell cycle was evaluated by fluorescence-activated cell sorting (FACS). The influence of LLLs on mitochondrial biogenesis (fission or fusion) and function (ATP, reactive oxygen species [ROS], nitric oxide [NO]) was evaluated by transmission electron microscope, FACS, quantitative real time polymerase chain reaction (q-PCR), and immunocytochemistry. Cell migration and cytoskeleton alteration (actin and tubulin) were evaluated using transwell assay, immunocytochemistry, enzyme-linked immunosorbent assay, and western blotting. Cell apoptosis was evaluated using FACS, immunocytochemistry, and western blotting. We investigated that certain influence of LLLs on MSCs in vitro 6 or 24 h after 1 h of LLL irradiation.
https://www.liebertpub.com/doi/abs/10.1089/scd.2016.0332
Kan Yin, Rongjia Zhu, Shihua Wang, Robert Chunhua Zhao

Low-level laser irradiation induces in vitro proliferation of mesenchymal regenerative medicines.

Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

Low-level laser irradiation stimulated the proliferation of mouse mesenchymal regenerative medicines without causing nuclear alterations. The biostimulation of mesenchymal regenerative medicines using laser therapy might be an important tool for regenerative therapy and tissue engineering.
https://www.ncbi.nlm.nih.gov/pubmed/24728250
Barboza CA, Ginani F, Soares DM, Henriques AC, Freitas Rde A.

Effect of Low-Level Laser Therapy on Human Adipose-Derived Regenerative Medicines: In Vitro and In Vivo Studies.

Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

Low-level laser irradiation stimulated the proliferation of mouse mesenchymal regenerative medicines without causing nuclear alterations. The biostimulation of mesenchymal regenerative medicines using laser therapy might be an important tool for regenerative therapy and tissue engineering.
https://www.ncbi.nlm.nih.gov/pubmed/26183254
Min KH, Byun JH, Heo CY, Kim EH, Choi HY, Pak CS.