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Mesenchymal regenerative medicines for cartilage regeneration in osteoarthritis

Osteoarthritis, Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

Osteoarthritis (OA) is a slowly progressive disease where cartilage of the synovial joint degenerates. It is most common in the elderly where patients experience pain and reduce physical activity. In combination with lack of conventional treatment, patients are often left with no other choices than arthroplasty. Over the last years, multipotent stromal cells have been used in efforts to treat OA. Mesenchymal stem/progenitor cells (MSCs) are stromal cells that can differentiate into bone, fat, and cartilage cells. They reside within bone marrow and fat.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605352/
Baldur Kristjánsson and Sittisak Honsawek

The Holy Grail of Orthopedic Surgery: Mesenchymal Regenerative Medicines—Their Current Uses and Potential Applications

Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

Only select tissues and organs are able to spontaneously regenerate after disease or trauma, and this regenerative capacity diminishes over time. Human regenerative medicine research explores therapeutic regenerative approaches to treat various conditions. Mesenchymal regenerative medicines (MSCs) are derived from adult regenerative medicines; they are multipotent and exert anti-inflammatory and immunomodulatory effects. They can differentiate into multiple cell types of the mesenchyme, for example, endothelial cells, osteoblasts, chondrocytes, fibroblasts, tenocytes, vascular smooth muscle cells, and sarcomere muscular cells. MSCs are easily obtained and can be cultivated and expanded in vitro; thus, they represent a promising and encouraging treatment approach in orthopedic surgery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494105/
Roberto Berebichez-Fridman, Ricardo Gómez-García, Julio Granados-Montiel, Enrique Berebichez-Fastlicht, Anell Olivos-Meza, Julio Granados, Cristina Velasquillo, and Clemente Ibarra

Mesenchymal regenerative medicines for cartilage repair

Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

It has been discovered that mesenchymal regenerative medicines (MSCs) in a polymeric carrier implanted into a cartilage and/or bone defect will differentiate to form cartilage and/or bone, as appropriate. Suitable polymeric carriers include porous meshes or sponges formed of synthetic or natural polymers, as well as polymer solutions. A presently preferred material is a polyglycolic acid mesh.
https://patents.google.com/patent/US6214369
Daniel A. Grande, Paul A. Lucas

Mesenchymal regenerative medicines for cartilage repair in osteoarthritis

Osteoarthritis, Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

Osteoarthritis (OA) is a degenerative disease of the connective tissue and progresses with age in the older population or develops in young athletes following sports-related injury. The articular cartilage is especially vulnerable to damage and has poor potential for regeneration because of the absence of vasculature within the tissue. Normal load-bearing capacity and biomechanical properties of thinning cartilage are severely compromised during the course of disease progression. Although surgical and pharmaceutical interventions are currently available for treating OA, restoration of normal cartilage function has been difficult to achieve.
https://stemcellres.biomedcentral.com/articles/10.1186/scrt116
Pawan K Gupta, Anjan K Das, Anoop Chullikana and Anish S Majumdar

Cartilage Repair by Mesenchymal Regenerative Medicines: Clinical Trial Update and Perspectives

Research StudiesBy Regenerative Medicine Therapy Clinic January 25, 2019

This review summarizes recently reported MSC-based clinical trials and discusses new research directions with particular focus on the potential application of MSC-derived extracellular vehicles, miRNAs and advanced gene editing techniques.
https://www.sciencedirect.com/science/article/pii/S2214031X17300049
Wayne Yuk-wai Lee and Bin Wang

Advances and Prospects in Regenerative Medicines for Cartilage Regeneration

Research StudiesBy Regenerative Medicine Therapy Clinic January 25, 2019

This review examines emerging trends on using regenerative medicines in cartilage tissue repair and regenerative medicine. It focuses on the characterization of cartilage regenerative medicines, the chondrogenic differentiation of regenerative medicines, and the various strategies, approaches, and clinical studies.
https://www.hindawi.com/journals/sci/2017/4130607/
Mingjie Wang, Zhiguo Yuan, Ning Ma, Chunxiang Hao, Weimin Guo, Gengyi Zou, Yu Zhang, Mingxue Chen, Shuang Gao, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Wenjing Xu, Shibi Lu, Shuyun Liu, and Quanyi Guo

Current Perspectives in Regenerative Medicine Research for Knee Cartilage Repair

Knee Research, Research StudiesBy Regenerative Medicine Therapy Clinic January 25, 2019

This review draws attention to the different perspectives on regenerative medicine therapy for repairing damaged cartilage in the knees. It also provides adequate research about the issue with cartilage repair and the role of regenerative medicine therapy during recovery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178263/
Patrick Orth, Ana Rey-Rico, Jagadeesh K Venkatesan, Henning Madry, and Magali Cucchiarini